PUBLICATIONS

• T. P. Zanos, S. H. Courellis, R. E. Hampson, V. Z. Marmarelis, T. W. Berger, “A multi-input modeling approach to    quantify hippocampal nonlinear dynamic transformations”, Proc. of IEEE 2006 International Conference of the EMBS,  New York, NY, 2006 (submitted)

• T. P. Zanos, S. H. Courellis, R. Hampson, V. Z. Marmarelis, T. W. Berger, “Modeling transformations of neural information flow in behaving rats: A multi-input / multi-output approach”, Proc. of 10^th Annual Fred S. Grodins Graduate Symposium, Los Angeles, CA, 2006 (pdf)

• T. P. Zanos, S. H. Courellis, R. Hampson, V. Z. Marmarelis, T. W. Berger, “Spatiotemporal kernels describing hippocampal nonlinear dynamics in behaving rats”, Proc. of 9^th Annual Fred S. Grodins Graduate Symposium, Los Angeles, CA, 2005 (pdf)

• V. Z. Marmarelis, T. P. Zanos, S. H. Courellis, T. W. Berger, “Boolean Modeling of Neural Systems with Point-Process Inputs and Outputs”, Proc. of IEEE 2006 International Conference of the EMBS, New York, NY, 2006 (submitted)

• S. H. Courellis, T. P. Zanos, M. C. Hsiao, R. E. Hampson, S. A. Deadwyler, V. Z. Marmarelis, T. W. Berger, “Modeling Hippocampal Nonlinear Dynamic Transformations with Principal Dynamic Modes”, Proc. of IEEE 2006 International Conference of the EMBS, New York, NY, 2006 (submitted)

• M. Hsiao, C. H. Chan, V. Srinivasan, A. Ahuja, G. Erinjippurath, T. P. Zanos, G. Gholmieh, D. Song, J. D. Wills, J. LaCross, S. H. Courelis, A. R. Tanguay, J. J. Granacki, V. Z. Marmarelis, T. W. Berger, “VLSI Implementation of a nonlinear neuronal model: A “Neural Prosthesis” to restore hippocampal trisynaptic dynamics, Proc. of IEEE 2006 International Conference of the EMBS, New York, NY, 2006 (submitted)

• M. Hsiao, V. Srinivasan, T. P. Zanos, A. Ahuja, G. Gholmieh, S. H. Courellis, D. Song, V. Z. Marmarelis, J. LaCross, J. D. Wills, A. R. Tanguay, J. J. Granacki, T. W. Berger, “Cortical Prosthesis Project: Proof-of-Concept in Hippocampal Slice”, Proc. of 10^th Annual Fred S. Grodins Graduate Symposium, Los Angeles, CA, 2006 (pdf)

RESEARCH ACTIVITIES

• Under Construction

PROJECTS

• Nonlinear and Nonstationary Modeling of Biomedical Systems
  Vasilis Z. Marmarelis, Ph.D. - Project Leader
  Biomedical Simulations Resource, USC
  This project is dedicated to the development of practical modeling methodologies using experimental or clinical data from physiological systems under natural operating conditions. The latter places the problem in its true operating context for the first time, and implies methodological capability to capture the dynamic nonlinearities and nonstationarities of the physiological systems in a stochastic broadband context. Due to the complexity of this fundamental problem, we have taken a gradualist step-by-step approach, building on the rigorous and general mathematical foundation of the Volterra-Wiener approach as extended and adapted to various applications over the last thirty years. It is gratifying to note that our efforts have succeeded in developing a solid foundation for a general modeling approach capable of tackling this problem in a practical context by fulfilling the specific objectives proposed for the current funding cycle. More information here.
   

• Cortical Prosthesis Testbed
  Theodore W. Berger, Ph.D. - Project Leader
  Biomimetic MicroElectronic Systems Engineering Research Center, USC
  The goal of this testbed is to develop prosthetic systems to replace cortical brain regions lost due to damage or disease, and to restore the cognitive functions supported by those brain regions. The Cortical Prosthesis team is focusing on a prosthetic for the hippocampal formation, a peri/allocortical brain system essential for long-term memory. Damage to the hippocampus is consistently associated with the pathological indicators and neurological symptoms related to traumatic brain injury, stroke, epilepsy, and Alzheimer’s disease. More information here.