PUBLICATIONS

JOURNAL PAPERS
• T. P. Zanos, S. H. Courellis, T. W. Berger, R. E. Hampson, S. A. Deadwyler, V. Z. Marmarelis, “Nonlinear Modeling of Causal Interrelationships in Neuronal Ensembles”, IEEE Trans. on Neural Systems and Rehabilitation Engineering, Vol. 15 (4), Aug. 2008, pp. 336-352.
• T. P. Zanos, V. Z. Marmarelis, R. E. Hampson, T. W. Berger, S. A. Deadwyler, “Boolean Modeling of Neural Systems with Point-Process Inputs and Outputs. Part II: Application to the Hippocampus”, Annals of Biomedical Engineering (accepted – under revisions)
• V. Z. Marmarelis, T. P. Zanos, T. W. Berger, “Boolean Modeling of Neural Systems with Point-Process Inputs and Outputs. Part I: Theory and Simulations”, Annals of Biomedical Engineering (accepted – under revisions)
• T. P. Zanos, S. P. Zanos, V. Z. Marmarelis, G. A. Ojemann, “Nonlinear relationship between local field potentials and single neuron spike timing in human temporal cortex”, (in preparation)
• T. P. Zanos, R. E. Hampson, S. A. Deadwyler, T. W. Berger, V. Z. Marmarelis, “Nonlinear Functional Connectivity Maps in the Hippocampus of Behaving Rats: A MIMO Approach”, (in preparation)

CONFERENCE PAPERS
• T. P. Zanos, R. E. Hampson, S. A. Deadwyler, T. W. Berger, V. Z. Marmarelis, “Functional Connectivity through Nonlinear Modeling: An Application to the Rat Hippocampus”, IEEE Engineering in Medicine and Biology Society Conference, Vancouver, Canada, 2008, pp. 5522-5525
• T. P. Zanos, S. H. Courellis, R. E. Hampson, S. A. Deadwyler, V. Z. Marmarelis, T. W. Berger, “A multi-input modeling approach to quantify hippocampal nonlinear dynamic transformations”, IEEE Engineering in Medicine and Biology Society Conference, New York, NY, 2006, pp. 4967-4970
• V. Z. Marmarelis, T. P. Zanos, S. H. Courellis, T. W. Berger, “Boolean Modeling of Neural Systems with Point-Process Inputs and Outputs”, IEEE Engineering in Medicine and Biology Society Conference, New York, NY, 2006, pp. 2114-2117
• S. H. Courellis, T. P. Zanos, M. C. Hsiao, R. E. Hampson, S. A. Deadwyler, V. Z. Marmarelis, T. W. Berger, “Modeling Hippocampal Nonlinear Dynamic Transformations with Principal Dynamic Modes”, IEEE Engineering in Medicine and Biology Society Conference, New York, NY, 2006, pp. 2300-2303
• M. Hsiao, C. H. Chan, V. Srinivasan, A. Ahuja, G. Erinjippurath, T. P. Zanos, G. Gholmieh, D. Song, J. D. Wills, J. LaCross, S. H. Courelis, A. R. Tanguay, J. J. Granacki, V. Z. Marmarelis, T. W. Berger, “VLSI Implementation of a nonlinear neuronal model: A “Neural Prosthesis” to restore hippocampal trisynaptic dynamics, IEEE Engineering in Medicine and Biology Society Conference, New York, NY, 2006, pp. 4396-4399

CONFERENCE ABSTRACTS/PRESENTATIONS
• T. P. Zanos, S. P. Zanos, G. A. Ojemann, V. Z. Marmarelis, “Nonlinear relationship between local field potentials and neural discharge in human temporal cortex, Poster Presentation, Society for Neuroscience Conference, Washington DC, 2008
• T. P. Zanos, S. H. Courellis, T. W. Berger, R. E. Hampson, S. A. Deadwyler, V. Z. Marmarelis, “Functional Connectivity in the rat hippocampus through nonlinear modeling in the context of a neuroprosthetic platform”, Poster Presentation, Society for Neuroscience Conference, San Diego, CA, 2007
• T. P. Zanos, S. H. Courellis, T. W. Berger, S. A. Deadwyler, R. E. Hampson, V. Z. Marmarelis, “Detecting Functional Connectivity between Neuronal Ensembles through Nonlinear Modeling”, Poster Presentation, Biomedical Engineering Society Annual Meeting, Los Angeles, CA, 2007
• T. P. Zanos, S. P. Zanos, S. H. Courellis, V. Z. Marmarelis, G. A. Ojemann, “Nonlinear dynamic modeling of the relationship between local field potentials and neural discharge in human temporal cortex”, Poster Presentation, Society for Neuroscience Conference, Atlanta, GA, 2006
• T. P. Zanos, S. H. Courellis, T. W. Berger, S. A. Deadwyler, R. E. Hampson, V. Z. Marmarelis, “Modeling the effects of interactions between CA3 hippocampal neurons on CA1 neuronal responses in behaving rats”, Oral Presentation, Biomedical Engineering Society Annual Meeting, Chicago, IL, 2006
• S. H. Courellis, T. P. Zanos, T. W. Berger, V. Z. Marmarelis, S.A. Deadwyler, R. E. Hampson, “A neural prosthesis for hippocampus: multi-input / multi-output model of the functional relationship between CA3 and CA1 hippocampal neurons in behaving rats”, Poster Presentation, Society for Neuroscience Conference, Atlanta, GA, 2006
• M. Hsiao, C. Chan, V. Srinivasan, T. P. Zanos, G. Erinjippurath, A. Ahuja, G. Gholmieh, J. D. Wills, J. Lscoss, S. H. Courellis, D. Song, A. R. Tanguay, J. J. Granacki, V. Z. Marmarelis, T. W. Berger, “A neural prosthesis for hippocampus: multi-input / multi-output model of the functional relationship between CA3 and CA1 hippocampal neurons in behaving rats”, Poster Presentation, Society for Neuroscience Conference, Atlanta, GA, 2006

PROJECTS

• Nonlinear and Nonstationary Modeling of Biomedical Systems
  Vasilis Z. Marmarelis, Ph.D. - Project Leader
  Biomedical Simulations Resource, USC
  This project is dedicated to the development of practical modeling methodologies using experimental or clinical data from physiological systems under natural operating conditions. The latter places the problem in its true operating context for the first time, and implies methodological capability to capture the dynamic nonlinearities and nonstationarities of the physiological systems in a stochastic broadband context. Due to the complexity of this fundamental problem, we have taken a gradualist step-by-step approach, building on the rigorous and general mathematical foundation of the Volterra-Wiener approach as extended and adapted to various applications over the last thirty years. It is gratifying to note that our efforts have succeeded in developing a solid foundation for a general modeling approach capable of tackling this problem in a practical context by fulfilling the specific objectives proposed for the current funding cycle. More information here.
   

• Cortical Prosthesis Testbed
  Theodore W. Berger, Ph.D. - Project Leader
  Biomimetic MicroElectronic Systems Engineering Research Center, USC
  The goal of this testbed is to develop prosthetic systems to replace cortical brain regions lost due to damage or disease, and to restore the cognitive functions supported by those brain regions. The Cortical Prosthesis team is focusing on a prosthetic for the hippocampal formation, a peri/allocortical brain system essential for long-term memory. Damage to the hippocampus is consistently associated with the pathological indicators and neurological symptoms related to traumatic brain injury, stroke, epilepsy, and Alzheimer’s disease. More information here.