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PUBLICATIONS
JOURNAL PAPERS
• T. P. Zanos, S. H. Courellis, T. W. Berger, R. E. Hampson, S. A.
Deadwyler, V. Z. Marmarelis, “Nonlinear Modeling of Causal
Interrelationships in Neuronal Ensembles”, IEEE Trans. on Neural
Systems and Rehabilitation Engineering, Vol. 15 (4), Aug. 2008, pp.
336-352.
• T. P. Zanos, V. Z. Marmarelis, R. E. Hampson, T. W. Berger, S. A.
Deadwyler, “Boolean Modeling of Neural Systems with Point-Process
Inputs and Outputs. Part II: Application to the Hippocampus”, Annals
of Biomedical Engineering (accepted – under revisions)
• V. Z. Marmarelis, T. P. Zanos, T. W. Berger, “Boolean Modeling of
Neural Systems with Point-Process Inputs and Outputs. Part I: Theory
and Simulations”, Annals of Biomedical Engineering (accepted – under
revisions)
• T. P. Zanos, S. P. Zanos, V. Z. Marmarelis, G. A. Ojemann,
“Nonlinear relationship between local field potentials and single
neuron spike timing in human temporal cortex”, (in preparation)
• T. P. Zanos, R. E. Hampson, S. A. Deadwyler, T. W. Berger, V. Z.
Marmarelis, “Nonlinear Functional Connectivity Maps in the
Hippocampus of Behaving Rats: A MIMO Approach”, (in preparation)
CONFERENCE PAPERS
• T. P. Zanos, R. E. Hampson, S. A. Deadwyler, T. W. Berger, V. Z.
Marmarelis, “Functional Connectivity through Nonlinear Modeling: An
Application to the Rat Hippocampus”, IEEE Engineering in Medicine
and Biology Society Conference, Vancouver, Canada, 2008, pp.
5522-5525
• T. P. Zanos, S. H. Courellis, R. E. Hampson, S. A. Deadwyler, V.
Z. Marmarelis, T. W. Berger, “A multi-input modeling approach to
quantify hippocampal nonlinear dynamic transformations”, IEEE
Engineering in Medicine and Biology Society Conference, New York,
NY, 2006, pp. 4967-4970
• V. Z. Marmarelis, T. P. Zanos, S. H. Courellis, T. W. Berger,
“Boolean Modeling of Neural Systems with Point-Process Inputs and
Outputs”, IEEE Engineering in Medicine and Biology Society
Conference, New York, NY, 2006, pp. 2114-2117
• S. H. Courellis, T. P. Zanos, M. C. Hsiao, R. E. Hampson, S. A.
Deadwyler, V. Z. Marmarelis, T. W. Berger, “Modeling Hippocampal
Nonlinear Dynamic Transformations with Principal Dynamic Modes”,
IEEE Engineering in Medicine and Biology Society Conference, New
York, NY, 2006, pp. 2300-2303
• M. Hsiao, C. H. Chan, V. Srinivasan, A. Ahuja, G. Erinjippurath,
T. P. Zanos, G. Gholmieh, D. Song, J. D. Wills, J. LaCross, S. H.
Courelis, A. R. Tanguay, J. J. Granacki, V. Z. Marmarelis, T. W.
Berger, “VLSI Implementation of a nonlinear neuronal model: A
“Neural Prosthesis” to restore hippocampal trisynaptic dynamics,
IEEE Engineering in Medicine and Biology Society Conference, New
York, NY, 2006, pp. 4396-4399
CONFERENCE ABSTRACTS/PRESENTATIONS
• T. P. Zanos, S. P. Zanos, G. A. Ojemann, V. Z. Marmarelis,
“Nonlinear relationship between local field potentials and neural
discharge in human temporal cortex, Poster Presentation, Society for
Neuroscience Conference, Washington DC, 2008
• T. P. Zanos, S. H. Courellis, T. W. Berger, R. E. Hampson, S. A.
Deadwyler, V. Z. Marmarelis, “Functional Connectivity in the rat
hippocampus through nonlinear modeling in the context of a
neuroprosthetic platform”, Poster Presentation, Society for
Neuroscience Conference, San Diego, CA, 2007
• T. P. Zanos, S. H. Courellis, T. W. Berger, S. A. Deadwyler, R. E.
Hampson, V. Z. Marmarelis, “Detecting Functional Connectivity
between Neuronal Ensembles through Nonlinear Modeling”, Poster
Presentation, Biomedical Engineering Society Annual Meeting, Los
Angeles, CA, 2007
• T. P. Zanos, S. P. Zanos, S. H. Courellis, V. Z. Marmarelis, G. A.
Ojemann, “Nonlinear dynamic modeling of the relationship between
local field potentials and neural discharge in human temporal
cortex”, Poster Presentation, Society for Neuroscience Conference,
Atlanta, GA, 2006
• T. P. Zanos, S. H. Courellis, T. W. Berger, S. A. Deadwyler, R. E.
Hampson, V. Z. Marmarelis, “Modeling the effects of interactions
between CA3 hippocampal neurons on CA1 neuronal responses in
behaving rats”, Oral Presentation, Biomedical Engineering Society
Annual Meeting, Chicago, IL, 2006
• S. H. Courellis, T. P. Zanos, T. W. Berger, V. Z. Marmarelis, S.A.
Deadwyler, R. E. Hampson, “A neural prosthesis for hippocampus:
multi-input / multi-output model of the functional relationship
between CA3 and CA1 hippocampal neurons in behaving rats”, Poster
Presentation, Society for Neuroscience Conference, Atlanta, GA, 2006
• M. Hsiao, C. Chan, V. Srinivasan, T. P. Zanos, G. Erinjippurath,
A. Ahuja, G. Gholmieh, J. D. Wills, J. Lscoss, S. H. Courellis, D.
Song, A. R. Tanguay, J. J. Granacki, V. Z. Marmarelis, T. W. Berger,
“A neural prosthesis for hippocampus: multi-input / multi-output
model of the functional relationship between CA3 and CA1 hippocampal
neurons in behaving rats”, Poster Presentation, Society for
Neuroscience Conference, Atlanta, GA, 2006
PROJECTS
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Nonlinear and Nonstationary Modeling of Biomedical Systems
Vasilis Z. Marmarelis, Ph.D. - Project Leader
Biomedical Simulations Resource, USC
This project is dedicated to the development of practical
modeling methodologies using experimental or clinical data from
physiological systems under natural operating conditions. The
latter places the problem in its true operating context for the
first time, and implies methodological capability to capture the
dynamic nonlinearities and nonstationarities of the
physiological systems in a stochastic broadband context. Due to
the complexity of this fundamental problem, we have taken a
gradualist step-by-step approach, building on the rigorous and
general mathematical foundation of the Volterra-Wiener approach
as extended and adapted to various applications over the last
thirty years. It is gratifying to note that our efforts have
succeeded in developing a solid foundation for a general
modeling approach capable of tackling this problem in a
practical context by fulfilling the specific objectives proposed
for the current funding cycle. More information
here.
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Cortical
Prosthesis Testbed
Theodore W.
Berger, Ph.D. - Project Leader
Biomimetic MicroElectronic Systems Engineering Research Center,
USC
The goal of this testbed is to
develop prosthetic systems to replace cortical brain regions
lost due to damage or disease, and to restore the cognitive
functions supported by those brain regions. The Cortical
Prosthesis team is focusing on a prosthetic for the hippocampal
formation, a peri/allocortical brain system essential for
long-term memory. Damage to the hippocampus is consistently
associated with the pathological indicators and neurological
symptoms related to traumatic brain injury, stroke, epilepsy,
and Alzheimer’s disease.
More information
here.
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