School of Medicine
School of Medicine
Welcome! We announce the arrival of Tim Lam, Ph.D. to join our team at the
Doheny Vision Research Center, Los Angeles, California USA.
You have reached the inhabitants of the laboratories of our Great Leader and Teacher
Alfredo A. Sadun, M.D., Ph.D.
Our fearless leader fights a never-ending battle with human blindness in an endless quest to eradicate the devastation and damage to the optic nerve.We, the crew of the Starship SadunLab, stand at the ready steering our efforts into yet uncharted territory for new cures for blindness.
Our Research Libraries
Our Hospitals
Our Credo
Our Campus
A little on our Commander-In-Chief...
Alfredo A. Sadun, M.D., Ph.D. aka Leader for a Free World without Blindness, The Admiral, Teacher, Pal, and Friend
Professor and F.L. Thorton Chair of Vision Science, Depts. of Ophthalmology and Neurological Surgery at the University of Southern California
Dr. Sadun earned both his M.D. and Ph.D. in Neuroanatomy from the Albert Einstein College of Medicine. He went on to complete a residency and chief residency at the Massachusetts Eye & Ear Infirmary, Harvard University. Then, he completed a combined clinical fellowship in neuro-ophthalmology at Boston University School of Medicine, Harvard Medical School, and the University of California Medical Center, San Francisco. To date, Dr. Sadun and his merry band of researchers at the Doheny Eye Institute have pioneered research in the optic nerve and its brain connections. They have also investigated causes of optic nerve disease including Leber's Hereditary Optic Neuropathy (LHON), and dysfunction in Alzheimer's disease. His research and clinical expertise in diseases of the optic nerve made him the choice to lead a team of investigators that determined the metabolic cause of an epidemic of optic neuropathy in Cuba, 1993-1994. His current research focuses on the areas of mitochondrial genetics with respect to LHON and mitigating retinal ganglion cell neuro-degeneration through cytokine induction. In addition to his academic tenure, Dr. Sadun is the Residency Director for the USC/Doheny Eye Institute Ophthalmology Program at the USC School of Medicine.
A Live View of our Commons ..............................and a look at our History
The many Facets of our School of Medicine from Basic Research to Patient Care
Research Activities:
Human visual neuro-anatomy
Plasticity and specificity in the mammalian central nervous system
Neuronal development and synaptic organization
Axon populations in the human optic nerve in development, aging and diseases
Cytokine interplay in retinal ganglion cell survival and death
Genetic and acquired causes of mitochondrial impairment in retinal ganglion cells and the optic axon
Neuroprotection
Clinical Interests:
Neuro-ophthalmology
Optic nerve disorders
Optics and psychophysics
Tests of different visual functions
Vision in AIDS and other CNS disorders
PPD-stained human optic nerve cross-sections display up to 1.2 million fibers
Normal Optic Nerve profile and a Leber's Optic Nerve profile
These technologies and experimental methods are in current use in the Sadun Labs:
1) Light Microscopy of conventional/modified morphology stains
2) Computer Image-Analysis and Morphometry
3) Immunohistochemistry and Confocal Microscopy
4) Cell/tissue Culture and Flow Cytometry
5) Electron Microscopy (TEM/SEM)
6) Molecular biological and protein chemistry techniques
Every spring in May, the world's eye experts gather at ARVO in Ft. Lauderdale to keep abreast of each other's work. Here, new alliances are made to further the fight against eye diseases.
We are affiliated with Los Angeles County Medical Center...
and are located on the USC Health Sciences campus.
For those of you new to the area, welcome
to the City of Los Angeles!
