Who am I

I am a Postdoctoral scholar in Department of Aerospace and Mechanical Engineering of University of Southern California (USC), supervised by Professor Eva Kanso, who also supervised my PhD study. Before I started pursuing my PhD degree, I obtained my B.E. degree in Engineering Mechanics from Tsinghua Univeristy (China) and M.S. degree in Mechanical Engineering from USC in 2010 and 2012 respectively. A recent CV can be found here.

You can also check out my profiles at Research Gate and Google Scholar.

What do I do

I am interested in understanding the fluid-solid interaction in biological system using mathematical and physical models (see more in Research page). My current project focuses on developing a quantitative framework of modeling ciliary transport in health and disease. This framework applies quantitative measures that link cilia mechanics to function in both healthy and diseased states, and tries to bridge the gap between biologists and physicists. I use regularized Stokeslet method, immersed boundary method, and tools from computer graphics to tackle these research questions. Below is a simple animations illustrating how elastic filaments can get synchronized via hydrodynamic coupling. Simulations are performed via regularzied Stokeslet method and visualized by VMD.

Computer Man

I also contribute in the research about the affinity measure for complex networks. The work can be applied to, but not limited to, cancer gene mutations and natural language processing. This work is lead by Professor Jun Guo in Beijing University of Posts and Telecommunications (BUPT).

Publications

Bistablility in the synchronization of actuated microfilaments. Hanliang Guo, Lisa Fauci, Michael Shelley, Eva Kanso. accepted to Journal of Fluid Mechanics.[ pdf (preprint)][ link ]

Motile cilia create fluid-mechanical microhabitats for the active recruitment of the host microbiome. Janna Nawroth*, Hanliang Guo*, Eric Koch, Elizabeth A. Heath-Heckman, John C. Hermanson, Edward Ruby, John Dabiri, Eva Kanso, Margaret McFall-Ngai. PNAS 114 (36), 9510-9516 (2017). (*: equal contribution) [ pdf ] [ pdf+SI ] [ link ]

Work featured in PNAS In This Issue, USC News, LabAnimal, BPoD.

A computational study of mucociliary transport in healthy and diseased environments. Hanliang Guo, Eva Kanso. European Journal of Computational Mechanics, 26, 4-30 (2017). [ pdf ] [ link ]

Evaluating efficiency and robustness in cilia design. Hanliang Guo, Eva Kanso. Phys. Rev. E, 93, 033119 (2016). [ pdf ] [ link ]

Cilia beating patterns are not hydrodynamically optimal. Hanliang Guo, Janna Nawroth, Yang Ding, Eva Kanso. Phys. Fluids, 26, 091901 (2014). [ pdf ] [ link ]

Inferring the Temporal Order of Cancer Gene Mutations in Individual Tumor Samples. Jun Guo, Hanliang Guo, Zhanyi Wang. PLoS ONE, 9(2): e89244 (2014).[ pdf ] [ link ]

An Activation Force-based Affinity Measure for Analyzing Complex Networks. Jun Guo, Hanliang Guo, Zhanyi Wang. Sci. Rep. 1, 113 (2011). [ pdf ] [ link ]

Miscellaneous

I am a big sports fan in general. I love watching ball games from soccer, basketball, to american football (Fight on USC!). In my spare time, I swim routinely, golf casually, but close to retiring from all contact-heavy ball games - I blame aging :).

I also do slow casual readings. The most recent one I have been reading is "Physics of the Future" by Michio Kaku. My list of readings can be found at Goodreads.com


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