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Topics
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Summary
Note
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Week 1
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Aug. 25 -
Aug. 29
(ch. 1)
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- Introduction to Biophysical Chemistry
Thermodynamics
- Heat, Energy, and Work
- First Law of Thermodynamics
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L1
L2
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Week 2
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Sept.3 -
Sept. 5
(ch. 1 & 2)
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- Enthalpy of reaction, Enthalpy of Formation
- Entropy and the Second Law of Thermodynamics
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Week 3
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Sept. 8 -
12
(ch.
2)
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- Entropy Measurements
- Entropy and hydrophobic interactions
- Third Law of Thermodynamics
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Week 4
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Sept. 15
- 19
(ch.
2)
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- Entropy of Substances and Chemical Reactions
- Spontaneity and Gibbs Free Energy
- Calculating DGorxn
and temperature dependence
- Protein-substrate binding
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Week 5
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Sept. 22
- 26
(selective
topics from ch. 3 & 4)
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- Thermodynamics of hydrogen-bonding and
hydrophobic interaction
- Application: DNA base recognition and replication
fidelity
- Application: DNA duplex stability and melting
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Week 6
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Sept. 29
– Oct. 3
(ch.
4)
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- Chemical Potential and Chemical Equilibrium
Solutions and Non-ideality
- Standard States in Solution
Exam 1, Wednesday, Oct. 1; in class
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Week 7
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Oct. 6 -
10
(ch.
4,5)
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- Acid Base Equilibria
- Temperature Dependence of Equilibrium Constant
- Redox Reactions
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Week 8
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Oct. 13 -
17
(ch.
5,6)
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Application: Biological Electron Transfer
Chemical Kinetics
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Week 9
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Oct. 20 -
24
(ch.
6)
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Week 10
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Oct. 27 -
31
(ch.
7)
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- Temperature Dependence and Transition State
Theory
- Reaction mechanisms
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Week 11
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Nov. 3 -
7
(ch.
8)
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- Kinetics and Mechanisms of Enzymatic Reactions
- Michaelis-Menten Equation and relationship to
energetics of catalysis
Exam 2, Wednesday Nov. 5; in class
LAB: Visualizing Enzyme Kinetics
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Week 12
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Nov. 10 -
14
(ch.
8)
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Class Presentation: Enzyme Lab
Structure
and Spectroscopy
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Week 13
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Nov. 17 -
21
(ch.
13)
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- Beers law, bio-chromophores
- Emission
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Week 14
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Nov. 24 -
26
(ch.
13)
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- Fluorescence Spectroscopy and FRET
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Week 15
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Dec. 1 -
Dec. 5
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- Bio-macro molecular structure: X-ray
crystallography, NMR and EPR
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Dec. 8 -
10
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Study Week; Final Reviews
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Dec. 15
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Final Exam, 8:00 – 10:00 am
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