Physical Chemistry for the Life Sciences
Fall Semester 2011

	Chem 432 homepage

Resources

THERMODYNAMICS A series of pages that show a very simplified system of four molecules in a set of evenly spaced energy levels. a-helix hydrogen bonding The entropy driven hydrophobic effect Pulling a single molecule of DNA and measuring the force Fidelity in DNA replication Mechanism of DNA Polymerase (Movies) REDOX REACTIONS 3D Structure of small water-soluble Cytochrome c protein - the electron carrier from the bc1 complex to CcO  General information about the terminal respiratory-chain redox protein:  cyctochrome c oxidase (CcO).  Includes 2D images, diseases links and links to research groups working on this protein. Information, including 3D structures, on the bc1 complex Find any protein structure that has been solved from the RCSB protein databank. KINETICS Timescales in Chemistry and Biology Reaction simulator.  Explore the forward and backward reaction kinetics at the molecular scale.  This Java simulation lets you experiment with changing the rates, temperature and concentration and graphs the time dependence of the molecular concentrations. Collision Theory and the steric factor - real reactive collision trajectories for the Br + HI reaction Viewing the fleeting transition state ENZYME KINETICS Michaelis-Menten enzyme kinetics Example of Lineweaver-Burke Analysis Explore the catalase enzyme Comparison of different catalysts on the decomposition of hydrogen peroxide SINGLE MOLECULE SPECTROSCOPY Using single molecule fluorescence to follow the kinetics of a single enzyme Near-Field (NSOM) PHOTOBIOLOGY Ultrafast kinetics - the photosynthetic reaction center Photosynthetic proteins: LH2 Fluorescence Spectroscopy of a single LH2 complex (Science 285, 400 (1999)) Photosynthetic proteins: Background PROTEIN STRUCTURE DETERMINATION Tutorial on Peptide and Protein Structure Home page for The Protein Data Bank (PDB) SCANNING PROBE MICROSCOPY STM image of atomically resolved graphite surface, and a long chain molecule on a graphite surface AFM of operation RNA polymerase.  The DNA is pulled through the RNA polymerase, which is bound to a surface.  (Movie also) THE HUMAN GENOME Capillary Array Electrophoresis (CAE). DOE Human Genome Program Report

?2002, Chemistry Dept.,  University of Southern California