Our project has two main aims. Our first aim is to determine possible MHC class II-associated antigenic peptides derived from Sjögren’s syndrome (SjS) autoantigens, using a computational model based on the crystal structure of I-Ag7 complex to the GAD65 peptide. Our second aim is to determine how MHC class II and autoantigen expression and distribution are different in lacrimal glands from BALB/c and NOD mice, using immunostaining and confocal microscopy.