Our observations in lacrimal glands from NOD mice indicate a clear difference in localization patterns of the M3 receptor. We hypothesize that the M3 receptors of diseased mice show sharp concentrated signals within lysosomal cavities of the cell. Furthermore, by utilizing the known GAD peptide antigen, our computational results have eliminated unlikely antigenic peptide candidates, and in doing so our findings have identified numerous peptides from the M3 receptor as potential antigenic peptides responsible for the immune system response in SjS. The peptides indicated as accessible antigens by the hydropathy profile include: 15, 131, and 507 of the M3 muscarinic receptor.